The two constraints are mutually exclusive(set_false_path has the highest priority).
You're 10ns clock has edges at 0, 10, 20, 30... You're 4ns clock has edges at 0, 4, 8, 12, 16, 20... TimeQuest will find the most restrictive relationship, which is launching at 10 and latching at 12, or 2ns. Note that right off the bat, that is a fraction of one of the periods. If you do a "multicycle -setup -end 2", then the latch edge moves out one of its periods and your setup relationship is 6ns. If you do a multicycle -setup -source 2, then it moves out one of the source periods, becoming a setup relationship of 12ns. Note that none of these are not necessarily multiples of either clock, so it's not true that it can only be a multiple of one of the clocks. What is true is that it moves a multiple of each clock.
So doing "multicycle -end -setup 2,3,4,5..." would give you setup relationships of 6, 10, 14, 18...
Doing "multicycle -source setup 2,3,..." would give you setup relationships of 12, 22,...
So those values are your options with multicycles setups. (I'm ignoring hold right now, as well as what happens if any of your registers are falling edge, which is a whole other set of analysis.)
Those are your options, but the question is, how does the circuit work? Does it launch data at time 0ns? If so, which edge latches it? Does it launch new data at 10ns? Which edge latches that? Let's say you launch on every edge, but write your latching circuit to latch at time 8ns and time 16ns, and this repeats over time, i.e. you latch at 8, 16, 28, 36, 48, 56,... You're most restrictive one is the 6ns setup relationship. This can be achieved with a multicycle setup -end of 2.
Let's say your circuit latched at times, 4, 16, 24, 36, 44, 56,... You're most restictive setup would be the launch at 0ns and latch at 4ns. In this case, multicycles can't do that. It's not one of the options, and you would have to do:
set_max_delay -from [get_clocks ...clk[0]] -to [get_clocks ...[clk2]] 4.0
I've only seen the need to do this one time, but it did come in handy.