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ok, I should have been more clear. I do have a 10pin connector on the board, but the JTAG lines to the FPGA (TCK, TMS, etc) are grounded. I program in active serial mode. But then I have no way of sending data back and forth. Hence my thought to repurpose the blaster as a generic SPI IO. Seems like is doable based on what you said, so I guess there is some reading in my future.
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The problem you will have is that the Active Serial signals on the 10-pin header are connected to the EPCS configuration EEPROM. You will not be able to "re-purpose" chip-select, since it is already in use by the EPCS device.
If you have other FPGA pins connected to a 100-mil header, then I would recommend using those pins. You can still use the USB-Blaster, but you will avoid possible conflicts with the AS interface.
Cheers,
Dave