Hi Matthias,
the problem started to appear on fully functional design. I found, that PC with my device freezes time from time. It was running correctly for hours or days until that freeze - there were running loads of read/write access, DMA read/writes without any problem. After some searching I found that in some situation the control software writes lots of data to my device (reconfiguration of control registers) and that in some cases freezes the PC. So I tried to remove as much as possible from my design to find which part could be responsible for this problem, but until now I did not find any part of my design responsible for freezing of the system - I've ended with design that does not transmit anything and the software only writes to my device...
Martin