Basic work flow question on Altera DSP Builder

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Qauartus should be helpful and tell you why. Do you run quartus from its block or have you got a top level your own project then added all required files from dspbuilder to your quartus project.

It could simple issue: if you click quartus block in simulink it then opens and loads project then it is up to you to click on run button.

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Yes I run Quartus from the "Run Quartus" Block in Simulink. Then try to compile in quartus and it never gets past 11%