Configuring clock domains with sdc files

You're create_generated_clock looks suspicious. I've never applied it to a net. If it's a register, apply it to the register. Also, I believe your source should work, but most users have the upstream source node as the source:

create_generated_clcok -name clock_RTL -divide_by 10 -source [get_ports clock_50_MHZ] [get_keepers {ada|readdata[0]}]

Also note that the register needs to be driven by clock_RTL. If it's a ripple clock feeding another ripple clock, then each stage needs to have a generated clock since clocks don't propogate through registers.