Using Synplify Pro with Quartus

I closed quartus and open it again and everything seems to work fine. I can´t explain why it didn´t work before.

Now I am able to run synplify from within Quartus.

What i would like to know is can synplify take the constraints already in place in the quartus project file and use these?

It seems that synplify ignores any Tco constraints. Why would this be?

I also see some assignments in the assignment editor have been reverted to old values. I don´t know if synplify had anything to do with it? I can´t imagine so.

Thanks