Hello
Are you looking to edit the memory contents at runtime? ( the .mif file is just used to hold the contents for compilation and the file itself is not uploaded to the chip 'as-is' )
If you are trying to edit the contents of the ram at runtime, check option "Allow In-System Content Editor ..." from the megafunctions wizard.
After programming your chip, use the In-System Content Editor to edit memory at runtime (Quartus II -> Tools -> In-system... )
@FvM QuartusII seems to have a pretty neat and simple mif/hex-file editor, accessable from New/Open-file dialogs..