I've had several ByteBlasterII's that either failed after a few uses or never worked. Some painful (partially due the fact Altera hasn't published a schematic for this device) investigation showed the problem to be weak vias on the PCB that weren't reliably plated through. Some vias on the board had been repaired/reinforced at the factory using a small length of wire (standard practice). Some apparently were missed during assembly/test, or were ready to fail but hadn't yet. After these were tracked down and repaired the blasters work fine.
Maybe the USB Blasters are subject to the same lack of quality control.
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