simple examples not work,give me idea

Hi ,everyone

examples within nios2 5.0 can't work(ep2s60f ,stratix2 high speed broad) , I load .sof successfully(ex. full_featured in niosII_stratixII_2s60_ES),

follow, I create a application base on hello_world,

check runas ->hardware ,

"Using cable "USB-Blaster [USB-0]", device 1, instance 0x00

Pausing target processor: not responding.

Resetting and trying again: FAILED

Leaving target processor paused"

What's means ?