I can't load my NIOS II application

Thank yuo for yours suggestions:

hippo - the pof is on EPCS4, when I try load sof by flash programmer, the same situation, than when I try debug application (Resetting and pausing target processor: FAILED Leaving target processor paused)

dannyjacobs - I think, I downoloaded the right NIOS in my board. Clock freq = 33.33MHz, Reset Nios pin is no drive (with default value VCC). About memory - I'll try use only OnChip memory and smallest NIOS application.

Thank you