Timing constraint problem while using altera ipcore

Once you have set up the clocks in your timing constraints and set up the optimal parameters as suggested by the advisor, there is little you can do except modify the design.

In my case I added pipeline stages until I could meet the speed I wanted, but if you don't have access to the IP core's internals it can be more difficult.

Having the coefficients load in a different clock domain could help because you could run it at a lower frequency than the data processing.