Question about Monitor

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I used Timing Optimization Advisor[TOA] to tweak my design. The results were not consistent. [some times the teaks seems to work and some times it doesn't. Some times there are variations in the normal cases[with no tweaks] that outperforms the cases with tweaks]

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I do not use these tools. However, a general recommendation would be to only use them when optimizing individual components, not an entire design. You may have a single poorly designed component that is affecting the entire design. Determine if all components need to run at the same clock rate, or whether the design can be arranged to have slower peripherals separated into another part of the design, and then access those components via a clock-crossing bridge.

Cheers,

Dave