This may sound like a hoaky answer but try it. I have personally experienced this several times and haven't been able to explain the cause.
1 - Close everything (Quartus, SoPC builder, and NIOS II IDE)
2 - Launch Quartus and open your project.
3 - Launch SoPC builder.
4 - Re-generate your SoPC design.
5 - Close SoPC builder (very important).
6 - Compile the project in Quartus.
7 - Launch the NIOS IDE.
8 - Make sure your system library is pointing to the correct PTF.
9 - Recompile your NIOS project and visually make sure that it is recompiling the system library.
10 - Now try it.
Jake