Hi, could anyone can tell me can i run linux on EP4CE6E22C8N? Is there any guide how to do this thank you

Hi,

Have you install Quartus software to your Linux computer?

The EP4CE6E22C8N is using Cyclone IV, here the link that you can check out that have documented example design etc.:

https://www.intel.com/content/www/us/en/programmable/products/fpga/cyclone-series/cyclone-iv/support.html

Regards.