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Which boards have you seen that use the FT2232? I've only ever seen the BeMicro use it. The "Arrow USB-Blaster" is significantly slower than a standard USB-Blaster when working with SignalTap II. I have a BeMicro and BeMicro-SDK interfaced to external FTDI UM245R and UM232H modules, and SignalTap II capture using the BeMicro is way slower than using the BeMicro-SDK. The FT2232C MPSSE mode can be operated at the same frequency as the bit-mode/byte-modes on the standard USB-Blaster, so I'm not sure what causes the speed difference ... probably software/driver support.
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I completely agree to the comment. I was thinking for a while that the pure FT2232 JTAG interface would be an interesting USB Blaster alternative in some situations. It's basically working, but low speed and instability of the driver (I need often need to kill the JTAG driver process after a communication failure) makes it very uncomfortable.