Regardless of its use for signal integrity analysis, which I think would be fairly new, the "toggle rate" setting has long been in Quartus for what gee's attachment says about checking pin-out restrictions like a toggling single-ended pin near a differential pin. An example of its use: Tell Quartus that a static single-ended pin like a board slot ID input has a toggle rate of zero. Setting toggle rate to zero lets Quartus know it may place that pin closer to a differential pin than the device handbook restrictions say is allowed for toggling single-ended pins. See http://www.altera.com/support/kdb/solutions/rd05052003_3407.html.