Hi Adam.
Questa will sometimes crash and disappear when it encounters confusing situations. Try running it all by itself, without calling it from another app. Try loading a simple, totally different HDL project to see if the problem changes.
The symptom you describe, disappearing when you add signals to the wave window, is very common with an incorrect license.
I have not able to replicate the issue due to bandwidth circumstances but here few ways I could think of
1. If you're sure that your lic file is ok, try to place it in a new folder. Call it for example msim.dat in toto folder.
In the environment variables, add the new environment.
example: LM_LICENSE_FILE set to c:\flexlm\license.dat
change it to
c:\toto\msim.dat;c:\flexlm\license.dat
In turn your Questa FSE license will be read first
2. Deleted all files in the Questa FSE project folder, except for the source files and re-compiled
Let me know if this is working
p/s: If any answer from community or Intel support are helpful, please feel free to mark as solution, give Kudos and rate 10/10 survey