My Quartus Desktop Shortcut is not functioning properly, I have attached a screenshot of the error it's giving me. Can someone please give me assistance and or advice with this matter. Thanks in advance!

Is it corrupted? Can you start it from a command line? TBH, it doesn't sound like a Quartus issue.​ It looks like a permission issue, or some kind IT override thing, which is messing with the permission/file.