As a test, I replaced the vqm by the interface module,
and Quartus goes further and does not complain about the APB_WIDTH parameter.
set_global_assignment -name SYSTEMVERILOG_FILE ../../INTERFACE/rng4_sa_intg.sv
#set_global_assignment -name VQM_FILE ../../rng4_sa_intg/synplify/synthesis/rng4_sa_intg_stratix10.vqm
So I think the rng4_sa_intg_stratix10.vqm is not even read out for some reaon.
Could it be that Quartus prime pro 21.1.0 has problem with more than one vqm (quartus 13.1 had no problem loading 2 vqm)?