contraints for polled/static interfaces

One approach is to provide timequest with an exception rather than a constraint. The two most common I use for these circumstances are set_max_delay and set_min_delay. With these you basically tell TimeQuest "Look, I don't care how long it takes to get from point A to point B with respect to the clock. All I care is that the delay from A to B is less than X and greater than Y". So for signals that you truly don't care what the delay is, you can use some outrageous max delay number of 1 second or something and a minimum delay of say 0. Just something that's easy for the fitter to meet. It can also be useful for asynchronous bus interfaces if you just want to keep the delays of all the signals in the bus within a certain tolerance relative to each other.