You need to be a little more specific.
What type of SERDES, eg., an LVDS or a transceiver based SERDES? The E variants do not have transceivers, so I assume you mean LVDS.
In many of the Altera device families, whether or not the LVDS I/O cell contains a SERDES depends on the I/O pins you've selected, i.e., dedicated LVDS I/Os contain either a TX or RX SERDES but not both.
A search of the Cyclone V handbook indicates these devices do have LVDS SERDES, eg., p55 of the PDF, see Figure 5-34: LVDS SERDES
http://www.altera.com/literature/hb/cyclone-v/cyclone5_handbook.pdf The width of the data bus into the SERDES block is 10, so that indicates the Cyclone V devices support a SERDES of up to 1:10 or 10:1.
If you post details on the device part number and your pin assignments, forum members can comment on whether you have selected an LVDS SERDES appropriately.
Cheers,
Dave