help about IO Expander

I use the MCU IO expander MAXII wants to.

In the extended IO 1.5V, 1.8V, 2.5V, 3.3V operating voltage with a variety of devices will be connected.

So attached to the system configuration shown in Figure 1, but what can it be?

Figure 1 is connected to the VCCIO voltage depending on the connected device to change the operating voltage.

The I2C bus to connect to the expansion of this design can it be?

Thanks