Hardware simulation is not enabled for the target SOPC Builder system ??

Not sure what your looking for. I assume you want to turn on hardware simulation files generation.

In SOPC builder GUI Click "next" button on the lower side of the window.

click on "Simulation.Create simulator files" checkbox in the upper section of the page.

This should create files you need to run simulation for your SOPC system.

However this step is not necessary if you do not need to simulate the design( using MODELSIM etc ). This is usually used to debug hardware problems.