DE10 Nano programmer failing to upload my program

Hi @HousseinKanso ,

As DE10-nano is SoC FPGA board, the HPS SoC should be included in the JTAG chain.

Based on the screenshot you provided, you need to click Auto Detect button to detect and choose the FPGA device, then FPGA and HPS devices will shown in the JTAG chain, as shown in the attached figure , right click on the 5CSEBA6 FPGA device then click Change File to choose your own .sof and download it.