The basic theory about static timing analysis

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Are you asking about "the basic theory of STA" or the abilities of it's implementation in Quartus and TimeQuest?

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Let us ask like this way, since in FPGA, we always do Synchronous Design, so I think STA in TimeQuest is always used to analyse synchronous design. But in theory, does that mean STA only be used for synchronous design? Can I use STA to analyse asynchronous design?

Thanks very much.