STA report using Quartus 18.0 pro

Hmm. For xtr_clk, based on the edges, the clock rises at 0 ns, falls at 100 ns, and rises again at 200, making for a period of 200 (correct) and a frequency of 5 MHz (incorrect). For msg_clk, the clock rises at 100 ns (which is a falling edge in uclock but I don't know if that makes a difference), falls at 300 ns, and rises again at 500 ns, making for a period of 500 (incorrect) and a frequency of 2 MHz (also incorrect).

I'm not sure what's going on here, but I rarely, if ever, see the -edges option used. Is there a reason you're using time relationships instead of frequency?