Saving Block Design Files get Not Responding Message

It's a problem with your network and/or file server. I'd be a bit paranoid about directly saving files to a file server. There is too much risk of a problem causing corrupted files. Make sure daily backups of the server are done. Keep lots of history in case a file goes bad and you don't notice for a while.

I'd suggest using a real version control system like git, svn, etc. These will insure that only good copies of revisions are saved. I use git even for my home hobby projects because it is easy to branch out and go back if something doesn't work out. Version control is free, and easy to use once you get the hang of it (which does take some effort). The ones I mentioned are simple for a software person to install and a real butt saver at times. In my opinion none of the paid packages are better than git or svn, so don't waste your money on them. Paid support for the free systems is available if you need help getting set up and learning how to use them.