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There is next to no information about this mode in the megacore documentation.
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In my opinion, the question can be answered by the general CIC gain expression, also given in CIC handbook. As far as I understand, the CIC core doesn't provide additional means to compensate for the gain change with variable decimation rate. So it has to be considered in your application.
When using arbitrary decimation rates, you also get arbitrary gain factors. Typically a LUT with compensation factors and a multiplier would be needed to achieve a rate independent scale factor. A simple method to avoid this additional effort is to use only power of 2 decimation factors.
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