PN EPM7160STI100-10 and EPM7256SRI208-10 EOL; Need Replacement

Are you looking for a drop in functional replacement, or a next generation solution that will require a new PCB design?

If the former, you are out of luck. That series went EOL years ago. Microchip/Atmel offers a direct functional drop in
replacement for some members of the EPM7xxx series, but only 128 macrocells or smaller, and not a 208p package.
For reference it is the ATF1500 series of programmable CPLD parts. Functional clones of the Altera EPM7000 series.
Current production, and they have tools to translate Altera .POF files to their .JED program file format.
But as I mentioned above they don't support more than 128 macrocells nor do they have a 208p package option.

If the latter, it depends on what package options you require, what I/O and system voltages you want, and how much
redesign you are capable of doing. I would have to assume you have the source verilog/vhdl, else you are going to be
in a bit of a pickle as is said.

You might want to look at either the MaxII, MaxV, or Max10 series parts that are in production now and will be for years.