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As another posted mentioned, you need to unplug the mouse/keyboard from the OTG connector when Linux boots. Then after Linux is booted, plug the mouse/keyboard into OTG connector. Then they should work. This was mentioned in the Gettting_Started_Guide.pdf that came with my board.
It also mentions that some mice/keyboards might not work with the DE10 due to an incompatibility problem. I have not run into that issue with my equipment -- I am using a Microsoft keyboard and mouse, and a non-powered hub.
There should be an icon on the Xfce desktop that allows you to enable/disable the USB gadget.
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How to disable the USB gadget before I cannot use mouse and keyboard control the Desktop?
I have tried to disable it in command line but it told me that "QXcbConnection: Could not connect to display"......
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