ContributionsMost RecentMost LikesSolutionsRe: Error while trying to run Questa simulator Hello, I too had the same issue on a fresh install of Quartus Prime 22.1std.0. I think I figured out why it is happening. In one of the tcl files, there is an erroneous double quote which, when removed, allows me to successfully launch Questa from Quartus. For me, I have Quartus installed in the default location, so when I navigate to "C:\intelFPGA_lite\22.1std\quartus\common\tcl\internal\nativelink" there is a file called qnativelinkflow.tcl .Open that file and go to line 122 which should say 'set questa_installation "$questa_fse_drectory'. Remove the double double quote and try launching the simulation from Quartus again. That worked for me. - Matt